Cancer and Cell Cycle Regulation

Posted by e-Medical PPT Friday, October 12, 2012
The Cell Cycle
The cell cycle has 4 periods, G1, S, G2, and M.
Quiescent cells, Go, can move into or out of G1 phase.

Major Checkpoint Monitoring Molecules
Cyclins
Cyclin Dependent Kinases (CDKs)
p53 - DNA damage   
RB - Retinoblastoma
APC - Anaphase Promotin Complex

p53 Anti-tumorigenic
p53 suppresses cell replication and growth when there is DNA damage.
Impact of less that diploid complement of p53.

p53 Control
mdm2 reduces the stability of p53 protein.
p19 arf inactivates mdm2 and allows activation of p53

Outcome of p53 Activation
Halts cell cycle until repair is completed.
Launches cell into apoptosis (programmed cell death).

Loss of RB
Enables continuous DNA synthesis
Defects in p16, cyclin D, Cdk4 have same result
Found in melanoma and liposarcoma
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