Prophylactic Antibiotics in Severe Acute Pancreatitis

Posted by e-Medical PPT Thursday, July 26, 2012
Acute pancreatitis spectrum of disease;
Mild, self-limiting disease requiring brief hospitalisation
Rapidly progressive, fulminant illness resulting in multi-organ failure, with mortality of 30-50%, months in hospital

Management strategies
  • Resuscitation
  • Analgesia
  • Investigation
  • Enteral nutrition
  • ERCP
  • Surgery
  • Pharmacological agents
  • Supportive
  • Prophylactic antibiotics
Prophylactic Antibiotics
Infection of necrotic tissue occurs 30-70% pts with pancreatic necrosis, associated increase mortality.
Infected necrosis may be more common if biliary origin
Majority infections develop 1st 4 weeks, peak week 2,3.
Experimental theory bacterial translocation from colon
Polymicrobial – enterobacter, staph, enterococci, streptococci,  anaerobes, pseudomonas, acinetobacter, candida.
Candida spp. More common SAP, use of broad spectrum antibiotics. Incidence up to 30% of necrotising pancreatitis, associated higher mortality.
Related Posts Plugin for WordPress, Blogger...

0 Responses to Prophylactic Antibiotics in Severe Acute Pancreatitis

Post a Comment

Share This


Subscribe by E-mail & receive updates your inbox!
Enter your email address:

Follow Us on Facebook

Blog Archive