Helicobacter Pylori and Hyperemesis Gravidarum

Posted by e-Medical PPT Sunday, July 22, 2012
Hyperemesis Gravidarum is usually a vexing problem for obstetricians Especially When conventional supportive therapy fails.

Hyperemesis gravidarum
Is the most severe manifestation of the spectrum of nausea and vomiting of pregnancy.
It complicates from 0.3 to 2% of all pregnancies

Materno – Fetal Morbidity
1) Dehydration, electrolyte imbalance, and acid base disturbances may lead to renal and hepatic injury
2) Patients who manifest continuous weight loss and electrolyte distrurbances may be at risk for growth restriction, fetal anomalies and decreased neonatal birth weight

Causes of  Hyperemesis gravidarum 
High levels of hCG ( multiple – molar)
Increased estrogen levels
Psychological factorS
High-fat diet
Helicobacter pylori(HP) ???

What is Helicobacter pylori?
Is a spiral-shaped gram negative rods found on gastric mucosa particularly the antrum (Howden, 1996).

Pathogenesis of HP Infection
Helicobacter Pylori causes a non-invasive infection of the gastric epithelium and the mucous layer that coats this epithelium.
The classical feature caused by this organism is chronic active gastritis.

The Association of H.pylori with Hyperemesis gravidarum
The elevated serum steroid hormone and human chorionic gonadotrophin (hCG), which leads to a shift in pH.
pregnancy-induced gastrointestinal dysmotility.
Altered humoral and cell-mediated immunity in pregnancy.
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