Lung transplantation

Posted by e-Medical PPT Wednesday, March 14, 2012
Lung transplantation is a surgical procedure in which a patient's diseased lungs are partially or totally replaced by lungs which come from a donor.James Hardy of the University of Mississippi performed the first human lung transplant in 1963.Following a single-lung transplantation, the patient survived for 18 days. 
Lung transplantation is the therapeutic measure of last resort for patients with end-stage lung disease who have exhausted all other available treatments without improvement.
chronic obstructive pulmonary disease (COPD), including emphysema;
idiopathic pulmonary fibrosis;
cystic fibrosis;
idiopathic (formerly known as "primary") pulmonary hypertension;
alpha 1-antitrypsin deficiency;
replacing previously transplanted lungs that have since failed;
other causes, including bronchiectasis and sarcoidosis.

Types of lung transplant
A lobe transplant is a surgery in which part of a living donor's lung is removed and used to replace part of recipient's diseased lung. This procedure usually involves the donation of lobes from two different people, thus replacing a single lung in the recipient. Donors who have been properly screened should be able to maintain a normal quality of life despite the reduction in lung volume.

Many patients can be helped by the transplantation of a single healthy lung. The donated lung typically comes from a donor who has been pronounced brain-dead.

Certain patients may require both lungs to be replaced. This is especially the case for people with cystic fibrosis, due to the bacterial colonisation commonly found within such patients' lungs; if only one lung were transplanted, bacteria in the native lung could potentially infect the newly transplanted organ.

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