Biological Therapy for Rheumatoid Arthritis

Posted by e-Medical PPT Tuesday, February 7, 2012
Rheumatoid arthritis
Is often an aggressive disease
May have potentially devastating consequences
Early, aggressive management can lead to successful control and remission

Morbidity & Mortality of Rheumatoid Arthritis
Average life expectancy shortened by 5-15 years.
Twice as likely to have MI or CVA
Increased risk of infection
Risk of lymphoma 3 times greater than general population

American College of Rheumatology Diagnostic Criteria for RA
Morning stiffness in joint for at least 1 hour.*
-Arthritis in 3 or more joint areas (PIP, MCP, wrist, elbow, ankle, MTP)*
-Arthritis of the hand (wrist, MCP, PIP)*
-Symmetric arthritis*
-Rheumatoid nodules
-Rheumatoid factor
-Radiographic changes

Anti-Cyclic Citrullinated Peptide Antibody
High titer anti-CCP may predict aggressive erosive disease.      

The Treatment of Rheumatoid Arthritis
Therapeutic Window of Opportunity
Erosive changes occur early in disease
Even a brief delay of therapy can have a significant impact on disease parameters years later
Early DMARD treatment appears to reset the rate of progression for years to come

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