Posted by e-Medical PPT Friday, October 22, 2010
Rickets disease of growing bones occurs in children before fusion of epiphysis due to un mineralized matrix at the growth plates.It is softening the bones in children potentially leading to fractures and deformity. Rickets is among the most frequent childhood diseases in many developing countries. The predominant cause is a vitamin D deficiency, but lack of adequate calcium in the diet may also lead to rickets (cases of severe diarrhea and vomiting may be the cause of the deficiency).Osteomalacia is the term used to describe a similar condition occurring in adults, generally due to a deficiency of vitamin D.
The primary cause of rickets is a vitamin D deficiency. Vitamin D is required for proper calcium absorption from the gut. Sunlight, especially ultraviolet light, lets human skin cells convert Vitamin D from an inactive to active state. In the absence of vitamin D, dietary calcium is not properly absorbed, resulting in hypocalcaemia, leading to skeletal and dental deformities and neuromuscular symptoms, e.g. hyperexcitability.A rare X-linked dominant form exists called Vitamin D resistant rickets.

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