Non-alcoholic fatty liver disease (NAFLD)

Posted by e-Medical PPT Tuesday, October 12, 2010
Non-alcoholic fatty liver disease (NAFLD) is one cause of fatty liver changes, when steatosis in the liver,not due to excessive alcohol use.Non-alcoholic steatohepatitis (NASH) is the most extreme form of NAFLD, which is regarded as a major cause of cirrhosis  of the liver of unknown cause. NAFLD is associated with insulin resistance and the metabolic syndrome (obesity, combined hyperlipidemia, diabetes mellitus (type II) and high blood pressure) and may respond to treatments originally developed for other insulin-resistant states (e.g. diabetes mellitus type 2), such as weight loss, metformin and thiazolidinediones.
Most patients with NAFLD have no or few symptoms. Infrequently, patients may complain of fatigue, malaise, and dull right-upper-quadrant abdominal discomfort. Mild jaundice  may, rarely, be noticed.
Disturbed liver enzymes are common, and liver ultrasound may show steatosis; it may also be used to exclude cholelithiasis. A biopsy of the liver is the only test that is widely accepted as definitively distinguishing NASH from other forms of liver disease, and can be used to assess the severity of the inflammation  and resultant fibrosis.

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1 Response to Non-alcoholic fatty liver disease (NAFLD)

  1. Anonymous Says:
  2. Is it Ideopathic or diet-induced or genetic???

     

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