Congenital Cytomegalovirus Infection

Posted by e-Medical PPT Sunday, October 31, 2010
Congenital cytomegalovirus infection refers to a condition where cytomegalovirus is transmitted in the perinatal period.CMV is one of the TORCH infections that lead to congenital abnormalities.Congenital CMV infection occurs when the mother suffers a primary infection (or reactivation) during pregnancy.The incidence of primary CMV infection in pregnant women in the United States varies from 1% to 3%. Healthy pregnant women are not at special risk for disease from CMV infection. When infected with CMV, most women have no symptoms and very few have a disease resembling infectious mononucleosis.
Generalized infection may occur in the infant, and can cause complications such as low birth weight, microcephaly, seizures, petechial rash similar to the "blueberry muffin" rash of congenital rubella syndrome, and moderate hepatosplenomegaly (with jaundice). Though severe cases can be fatal, with supportive treatment most infants with CMV disease will survive. However, from 80% to 90% will have complications within the first few years of life that may include hearing loss, vision impairment, and varying degrees of mental retardation.

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