Community-Acquired Methicillin-Resistant Staphylococcus aureus

Posted by e-Medical PPT Friday, October 22, 2010
Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium responsible for several difficult-to-treat infections in humans.MRSA is, by definition, any strain of Staphylococcus aureus bacteria that has developed resistance to beta-lactam antibiotics which include the penicillins and the cephalosporins.
S. aureus most commonly colonizes the anterior nares, although the respiratory tract, opened wounds, intravenous catheters, and urinary tract are also potential sites for infection. Healthy individuals may carry MRSA asymptomatically for periods ranging from a few weeks to many years. Immunocompromised patients are at a significantly greater risk of symptomatic secondary infection.
The most common manifestations of CA-MRSA are skin infections such as necrotizing fasciitis or pyomyositis,necrotizing pneumonia, infective endocarditis (which affects the valves of the heart), or bone or joint infections.CA-MRSA often results in abscess formation that requires incision and drainage.
CA-MRSA are resistant to traditional anti-staphylococcal beta-lactam antibiotics, such as cephalexin.Vancomycin and teicoplanin are glycopeptide antibiotics used to treat MRSA infections.

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