Tumour Markers In Gynecology

Posted by e-Medical PPT Friday, September 24, 2010
Tumor markers are glycoproteins that are usually detected by monoclonal antibodies. Each tumor marker has a variable profile of usefulness for screening, determining diagnosis and prognosis, assessing response to therapy, and monitoring for cancer recurrence. They are produced by tumor cells in response to cancer or certain benign conditions and indicate biological changes that signal the existence of malignancy. These soluble molecules can usually be detected in elevated quantities in the blood, urine, or body tissues of patients with certain types of cancer.
Gynecologic malignancies include ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms.
Gynaecological Tumour Markers are,
  • Human Chorionic Gonadotrophin (HCG)
  • Alfa Feto Protein (AFP)
  • Cancer Antigen-125 ( CA125)
  • CA 19-9
  • Carcino Embryonic Antigen (CEA)
  • Placental Alkaline Phosphtase (PLAP)
  • Squamous Cell Carcinoma Antigen (SCCA)
  • CA15-3, ( Also known as HER-2neu, OVX1, OVX2)
  • Macrophage Colony Stimulating Factor (MCSF)
  • Tumour Associated Trypsin Inhibitor (TATS)
  • Galactosyl Transferase Associated with Tumour ( GAT)
  • Alfa Amylase
  • Lactate Dehydrogenase (LDH)
  • Tumour Associated Glycoprotein-72 (TAG-72
  • Estrogens, Progesterone, Androgen
The primary use of CA-125 measurement is to monitor the disease status of patients with ovarian cancer, such as detecting early recurrence or assessing chemoresponse during chemotherapy.eta-hCG is expressed in human fetal tissue and cancer cells of various histologic types.Increased levels of beta-hCG occur in patients with choriocarcinoma of the uterus, embryonal carcinomas, polyembryomas, mixed cell tumors, and, less commonly, dysgerminomas. Both beta-hCG and human placental lactogen (hPL) are the most useful markers for trophoblastic disease and can be localized in syncytiotrophoblasts of partial and complete hydatidiform moles.

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