Gastric Cancer

Posted by e-Medical PPT Saturday, September 25, 2010
Gastric cancer can develop in any part of the stomach and may spread throughout the stomach and to other organs.Infection by Helicobacter pylori is believed to be the cause of most stomach cancer while autoimmune atrophic gastritis, intestinal metaplasia and various genetic factors are associated with increased risk levels. American Cancer Society lists the following dietary risks, and protective factors, for stomach cancer: "smoked foods, salted fish and meat, and pickled vegetables.Nitrates and nitrites are substances commonly found in cured meats.
Gastric adenocarcinoma is a malignant epithelial tumor, originating from glandular epithelium of the gastric mucosa. Stomach cancers are overwhelmingly adenocarcinomas (90%).Histologically, there are two major types of gastric adenocarcinoma:intestinal type or diffuse type.Intestinal type adenocarcinoma tumor cells describe irregular tubular structures, harboring pluristratification, multiple lumens, reduced stroma.Diffuse type adenocarcinoma (mucinous, colloid, linitis plastica) Tumor cells are discohesive and secrete mucus which is delivered in the interstitium producing large pools of mucus/colloid.
Surgery is the most common treatment. The surgeon removes part or all of the stomach, as well as the surrounding lymph nodes, with the basic goal of removing all cancer and a margin of normal tissue. Depending on the extent of invasion and the location of the tumor, surgery may also include removal of part of the intestine or pancreas. Tumors in the lower part of the stomach may call for a Billroth I or Billroth II procedure.Endoscopic mucosal resection is a treatment for early gastric cancer.

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