Anaphylaxis is Classified as a type I hypersensitivity, which is triggered when an antigen binds to IgE antibodies on mast cells based in connective tissue throughout the body, which leads to degranulation of the mast cells.These immune mediators cause many symptoms, including common symptoms of allergic reactions, such as itching, hives, and swelling. Anaphylactic shock is an allergic reaction to an antigen that causes circulatory collapse and suffocation due to bronchial and tracheal swelling.
Anaphylaxis is a medical emergency which may require resuscitation measures such as airway management, supplemental oxygen, large volumes of intravenous fluids, and close monitoring.Administration of adrenaline is the treatment of choice with antihistamines and steroids often used as adjuncts.
Epinephrine (adrenaline) is the primary treatment for anaphylaxis with no absolute contraindication to its use.pinephrine improves airway patency, improves blood pressure, and may be life-saving. The recommended dose is 500 µg (or 0.5 mL adrenaline injection 1 in 1000) given intramuscularly.If necessary, it can also be given intravenously using dilute solution.Epinephrine autoinjector is provided for self-prescription.