Hyponatremia and Osmotic Demyelination Syndrome

Posted by e-Medical PPT Tuesday, August 31, 2010
Osmotic Demyelination Syndrome or Central pontine myelinolysis is a neurologic disease caused by severe damage of the myelin sheath of nerve cells in the brainstem, in the pons.It can occur outside the pons also.The most common cause of Osmotic Demyelination Syndrome is the rapid correction of low blood sodium levels (hyponatremia).

Risk factors for developing Central pontine myelinolysis
  • Hematopoietic stem cell transplantation.
  • Alcoholism:When alcoholics are treated for hyponatremia, an overly rapid rate of correction can lead to CPM.
  • Severe liver disease
  • Liver transplant patients
  • Severe burns
  • Malnutrition
  • Hyperemesis gravidarum
Frequently observed symptoms in this disorder are acute para- or quadraparesis, dysphagia, dysarthria, diplopia, loss of consciousness, and other neurological symptoms associated with brainstem damage. The patient may experience locked-in syndrome where cognitive function is intact, but all muscles are paralyzed with the exception of eye blinking. These result from a rapid myelinolysis of the corticobulbar and corticospinal tracts in the brainstem.

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1 Response to Hyponatremia and Osmotic Demyelination Syndrome

  1. Doctor house Says:
  2. Very good Topic
    thank you man
    http://medxforum.com/vb/forum.php

     

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