Acute Pancreatitis

Posted by e-Medical PPT Friday, August 6, 2010
Acute pancreatitis is a sudden inflammation of the pancreas.Depending on its severity, it can have severe complications and high mortality despite treatment.
Gallstones and alcohol abuse account for almost 80% of hospital admissions for acute pancreatitis.Normally, the pancreas secretes pancreatic fluid through the pancreatic duct to the duodenum. This pancreatic fluid contains digestive enzymes in an inactive form and inhibitors that inactivate any enzymes that become activated on the way to the duodenum. Blockage of the pancreatic duct by a gallstone stuck in the sphincter of Oddi stops the flow of pancreatic fluid. Usually, the blockage is temporary and causes limited damage, which is soon repaired. But if the blockage remains, activated enzymes accumulate in the pancreas, overwhelm the inhibitors, and begin to digest the cells of the pancreas, causing severe inflammation.
Almost everyone with acute pancreatitis suffers severe abdominal pain in the upper abdomen, below sternum. The pain often penetrates to the back in about 50% of people.Most people feel nauseated and have to vomit.
In severe acute necrotizing pancreatitis pancreatic fluid may escape into the abdominal cavity, which decreases blood volume and results in a large drop in blood pressure, possibly causing shock.
Elevated serum amylase and lipase levels, in combination with severe abdominal pain, often trigger the initial diagnosis of acute pancreatitis.Serum lipase rises 4 to 8 hours from the onset of symptoms and normalizes within 7 to 14 days after treatment.Serum amylase may be normal (in 10% of cases) for cases of acute or chronic pancreatitis (depleted acinar cell mass) and hypertriglyceridemia.

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2 Responses to Acute Pancreatitis

  1. Adi Munthe Says:
  2. Thank you very much...really help me for reminding

  3. thanx, it's very useful!


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