Acute Interstitial nephritis

Posted by e-Medical PPT Friday, August 27, 2010
Acute Interstitial nephritis is a form of nephritis affecting the interstitium of the kidneys surrounding the tubules.This disease is also caused by other diseases and toxins that do damage to the kidney. Both acute and chronic tubulointerstitial nephritis can be caused by a bacterial infection in the kidneys, known as pyelonephritis. The most common cause is by an allergic reaction to a drug. The drugs that are known to cause this sort of reaction are antibiotics such as penicillin and cephalexin, and nonsteroidal anti-inflammatory drugs, such as aspirin. The symptoms of acute tubulointerstitial nephritis are fever ,rash and enlarged kidneys. Some people experience dysuria, and lower back pain.
  • Urinary findings include:
  • Eosinophiluria
  • Hematuria
  • Sterile pyuria: white blood cells and no bacteria
In most cases of acute tubulointerstitial nephritis, the function of the kidneys will return after the harmful drug is not taken anymore, or when the underlying disease is cured by treatment. If the illness is caused by an allergic reaction, a corticosteroid may speed the recovery kidney function.

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