Posted by e-Medical PPT Friday, June 11, 2010
Thrombophilia is the tendency to develop thrombosis  due to an abnormality in the system of coagulation.Hereditary defects in one or more of the clotting factors can cause the formation of dangerous blood clots.
The most common symptoms of thrombophilia are deep vein thrombosis  and pulmonary embolism , two conditions referred to together as venous thromboembolism.Deep vein thrombosis  is characterized by pain, swelling and redness of the limb. It may lead to long-term swelling and heaviness in a proportion of cases due to damage to valves in the veins. The clot may also break off and embolise to the lungs. Depending on the size and the location of the embolus this may lead to sudden-onset shortness of breath, chest pain, palpitations and may be complicated by collapse, shock and cardiac arrest. Venous thrombosis may also occur in more unusual places: in the brain (cerebral venous sinus thrombosis), liver (portal vein thrombosis and hepatic vein thrombosis), mesenteric vein, kidney (renal vein thrombosis) and possibly the veins of the arms.

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