Myelodysplastic Syndromes

Posted by e-Medical PPT Friday, June 18, 2010
Myelodysplastic syndromes (MDS) are a collection of hematological conditions united by ineffective production of myeloid blood cells and risk of transformation to acute myeloid leukemia (AML). Myelodysplastic syndromes has been found in humans, cats and dogs. Anemia requiring chronic blood transfusion is frequently present.
Myelodysplastic syndromes are bone marrow stem cell disorders resulting in disorderly and ineffective hematopoiesis (blood production) manifested by irreversible quantitative and qualitative defects in hematopoietic (blood-forming) cells. In a majority of cases, the course of disease is chronic with gradually worsening cytopenias due to progressive bone marrow failure. Approximately one-third of patients with MDS progress to AML within months to a few years.There is no cure for myelodysplastic syndromes. Treatment for myelodysplastic syndromes usually focuses on reducing or preventing complications of the disease and of treatments. In certain cases, myelodysplastic syndromes are treated with a bone marrow transplant, which may help prolong life.

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