HEMOLYTIC UREMIC SYNDROME

Posted by e-Medical PPT Tuesday, June 15, 2010
HEMOLYTIC UREMIC SYNDROME(HUS) is part of microangiopathic hemolytic anemia that encompass Thrombotic thrombocytopenic purpura (TTP) and HUS. The classic childhood case of HUS occurs after bloody diarrhea caused by a strain of E. coli that expresses Shiga-like toxin or EHEC (Enterohemorrhagic E. coli). HUS follows an influenza-like or gastrointestinal (GI) prodrome with bleeding manifestations, severe oliguria, hematuria, a microangiopathic hemolytic anemia, and occatinally prominent neurologic changes.The typical pathophysiology involves the shiga-toxin binding to proteins on the surface of glomerular endothelium and inactivating a metalloproteinase ADAMTS13.Once the ADAMTS13 is disabled multimers of vWF form and initiate platelet activation and cause microthrombi formation. In contrast with typical DIC , coagulation factors are not consumed in HUS and the coagulation screen, fibrinogen level, and assays for fibrin degradation products such as "D-Dimers", are generally normal despite the thrombocytopenia.

Related Posts Plugin for WordPress, Blogger...

0 Responses to HEMOLYTIC UREMIC SYNDROME

Post a Comment

We are on Google+

Share This

GET UPDATES!!!

Subscribe by E-mail & receive updates your inbox!
Enter your email address:

Follow Us on Facebook

Blog Archive