Gestational Trophoblastic Disease (GTD)_Hydatidiform Mole

Posted by e-Medical PPT Wednesday, June 23, 2010
Gestational trophoblastic disease encompasses several disease processes that originate in the placenta. These include complete and partial moles, placental site trophoblastic tumors, choriocarcinomas, and invasive moles.
A complete mole contains no fetal tissue.90% are 46,XX, and 10% are 46,XY.1,2 Complete moles can be divided into 2 types:Androgenetic complete mole and Biparental complete mole(The biparental complete mole is rare).With a partial mole, fetal tissue is often present. Fetal erythrocytes and vessels in the villi are a common finding. The chromosomal complement is 69,XXX or 69,XXY.As in a complete mole, hyperplastic trophoblastic tissue and swelling of the chorionic villi occur.
Vaginal bleeding in the first trimester is the most common  symptom of a complete mole.Molar tissue separates from the decidua, causing bleeding. The uterus may become distended by large amounts of blood, and dark fluid may leak into the vagina. This symptom occurs in 50% of cases.And Patients may also report Hyperemesis Gravidarum. This is due to extremely high levels of human chorionic gonadotropin.

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