CHRONIC MYELOPROLIFERATIVE DISORDERS

Posted by e-Medical PPT Sunday, June 13, 2010
The myeloproliferative diseases(MPD) are a group of diseases of the bone marrow in which excess cells are produced. They are related to, and may evolve into, myelodysplastic syndrome and acute myeloid leukemia.There are four main myeloproliferative diseases, which can be further categorized by the presence of the Philadelphia chromosome:
Philadelphia Chromosome "positive" -Chronic myelogenous leukemia (CML)
Philadelphia Chromosome "negative" - Polycythemia vera (PV),Essential thrombocytosis(ET),Myelofibrosis (MF)
All MPDs arise from precursors of the myeloid lineage in the bone marrow.Depending on the type of the MPD, diagnostic tests may include red cell mass determination,bone marrow aspirate and trephine biopsy,oxygen saturation and carboxyhaemoglobin level,neutrophil alkaline phosphatase level, vitamin B12 and serum urate.

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