Blood groups and Rhesus factor

Posted by e-Medical PPT Friday, June 4, 2010

A blood group is a classification of blood based on the presence or absence of inherited antigenic substances on the surface of red blood cells.These antigens may be proteins, carbohydrates, glycoproteins, or glycolipids, depending on the blood group system.Several of these red blood cell surface antigens that stem from one allele (or very closely linked genes), collectively form a blood group system.
Many pregnant women carry a fetus with a different blood type from their own, and the mother can form antibodies against fetal RBCs. Sometimes these maternal antibodies are IgG, a small immunoglobulin, which can cross the placenta and cause hemolysis of fetal RBCs, which in turn can lead to hemolytic disease of the newborn.

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