Anemia of chronic disease

Posted by e-Medical PPT Wednesday, June 2, 2010
Anemia of chronic disease is a form of anemia seen in chronic illness e.g. from chronic infection, chronic immune activation, or malignancy.In Anemia of chronic disease,In response to the inflammatory cytokines (IL-6) the liver produces increased amounts of hepcidin. Hepcidin in turn stops ferroportin from releasing iron stores. Inflammatory cytokines also appear to affect other important elements of iron metabolism, including decreasing ferroportin expression, and probably directly blunting erythropoiesis by decreasing the ability of the bone marrow to respond to erythropoietin.Anemia of chronic disease may also due to the neoplastic disorder and non infectious inflammmatory diseases. Neoplastic disorder include Hodgkin’s disease lung and breast carcinoma and non infectious inflammmatory diseases include Rheumatoid arthritis and systemic lupus erythematosus.
Anemia of chronic disease is often a mild normocytic anemia, but can sometimes be more severe, and can sometimes be a microcytic anemia.

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